Fertility-Regulating Kiss1 Neurons Arise from Hypothalamic Pomc-Expressing Progenitors
نویسندگان
چکیده
منابع مشابه
Loss of leptin receptors on hypothalamic POMC neurons alters synaptic
32 Adaptive changes in hypothalamic neural circuitry occur in response to alterations in 33 nutritional status. This plasticity at hypothalamic synapses contributes to the control of food 34 intake and body weight. Here we show that genetic ablation of leptin receptor gene 35 expression in POMC neurons (POMC: Lepr GFP) induces alterations at synapses on 36 POMC neurons in the arcuate nucleus of...
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Neuronal networks originating in the hypothalamic arcuate nucleus play fundamental roles in the control of energy balance. Neuropeptide Y (NPY)-producing neurons in the arcuate nucleus stimulate food intake, whereas arcuate nucleus neurons that release the proopiomelanocortin (POMC)-derived peptide alpha-melanocyte-stimulating hormone (alpha-MSH) potently reduce food intake. Relatively little a...
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Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Ageing reduces hypothalamic autophagy and α-MSH levels, and aged-mice phenocopy, the adiposity and l...
متن کاملActivation of inwardly-rectifying k+ channels in hypothalamic POMC neurons: role in integrating synaptic and metabolic input
Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in mammals. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced-green fluorescent protein (EGFP) to perform visualized, whole-cell patch recordings from pre-pubertal female hypothalamic slices. The mouse POMC-EGFP neurons expressed the same endogenous conductance ...
متن کاملAppetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons
Corticolimbic circuits involving the prefrontal cortex, amygdala, and ventral striatum determine the reward value of food and might play a role in environmentally induced obesity. Chemical manipulation of the nucleus accumbens shell (AcbSh) has been shown to elicit robust feeding and Fos expression in the hypothalamus and other brain areas of satiated rats. To determine the neurochemical phenot...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2015
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3614-14.2015